Conditions We Cover
Expert second opinions for serious and complex conditions.
WorldCare Multidisciplinary MSOs are available for 100+ conditions that have high medical and emotional complexity, like cancer, Alzheimer’s, and heart disease.
We specialize in these conditions because of their complexity and fast-moving diagnostic and care innovations.
Coverage may vary by health plan. Members should contact their benefits administrator or insurance provider for details.

All Cancers and serious tumors
All neoplastic conditions, which include malignant tumors (cancers) and serious benign tumors 1

Spine
- Major spinal trauma²
- Infection: osteomyelitis/discitis
- Neoplasms: benign or malignant tumors

Breast health
- Cancer
- Abscess

Cardiovascular
- Cardiac infarction
- Aneurysm of great vessels
- Vasculitis, myocarditis
- Cardiac tumors
- Cardiac failure
- Cardiac myopathy
- Cardiac valve disease
- Pericarditis, Cardiac tamponade
- Cardiac arrhythmias

Congenital disabling disorders
- Related Cancers including:
- Thyroid
- Pancreas
- Pituitary gland
- Hashimoto’s thyroiditis
- Disabling diabetic complications

Endocrinology
- Related Cancers including:
- Thyroid
- Pancreas
- Pituitary gland
- Hashimoto’s thyroiditis
- Disabling diabetic complications

Gastroenterology
- Related Cancers including:
- Esophagus
- Stomach, small and large intestines, rectum
- Liver, spleen, pancreas, gall bladder
- Peritoneum
- Infection
- Pancreatitis
- Peritoneal infections

Genitourinary
- Related Cancers including:
- Kidney
- Ureter and urinary bladder
- Testicles, prostate
- Renal failure
- Complicated renal transplant

Gynecology
- Related Cancers including:
- Ovary
- Uterus/fallopian tube

Hematology
- Complications of Sickle cell disease and Thalassemia
- Leukemia
- Multiple myeloma
- Lymphoma
- Waldenstrom Macroglobulinemia
- Severe anemia

HIV infection/AIDS

Musculoskeletal
- Cancer
- Infections
- Bone and joint infections
- Myositis
- Trauma
- Complicated fracture: pelvis, hip, rib
- Amputation
- Rheumatoid arthritis
- Marfan syndrome
- Muscular dystrophy

Neurology
- Neurodegenerative disorders
- Alzheimer’s disease
- Multiple sclerosis
- Parkinson’s disease
- Amyotrophic lateral sclerosis (ALS)
- Motor Neuron disease (MND)
- Vascular disorders
- Intracranial aneurysm
- Vascular malformation:
- Brain and spinal cord
- Brain and spinal cord embolism
- Disabling cerebral vascular accident
- Related Cancers including:
- Brain
- Spinal cord
- Trauma
- Traumatic brain and spinal cord injury
- Coma
- Infection
- Brain and spinal cord abscess
- Encephalomyelitis
- Idiopathic intracranial hypertension
- Paralysis caused by any of the above

Ophthalmology
- Sudden onset blindness
- Retinal detachment

Otolaryngology
- Related Cancers including:
- Paranasal sinuses/salivary glands
- Pharynx/larynx
- Vocal cords
- Tongue and buccal cavity
- Sudden onset deafness
- Traumatic facial injury

Respiratory tract
- Related Cancers including:
- Lung, trachea
- Thymus
- Respiratory failure
- Pulmonary embolism
- Chronic obstructive airways disease/emphysema
- Traumatic injury to the lung/pneumothorax
- Cystic fibrosis
- Heart/lung transplant

Skin/Dermatology
- Melanoma
- Complications from major burns

Mental Health
- Bipolar disorder
- Generalized anxiety disorder (GAD)
- Major depression
- Post-traumatic stress disorder
1 All neoplastic conditions: A) Coverage includes benign tumors that are clinically significant, complex, and pose a risk to health due to their size, location, or potential to cause complications. B) Benign tumors/cysts that are asymptomatic, non-progressive, and do not require medical intervention are excluded from the coverage. This would typically include benign tumors that are small, stable, and unlikely to cause complications.
2 Major Spinal Trauma: A) MSO can be provided only after member has received critical care and has seen a local specialist. B) Condition must have caused or could lead to partial or total loss of motor and/or sensory function below the level of injury. C) Includes: Burst fractures, fracture dislocation, odontoid fractures, hyperflexion/ hyperextension injuries, penetrating injuries.
New and Notable
Mental wellbeing enhancement adds psychologist input to WorldCare's multidisciplinary team reviews. It is included in our Premier Cancer and Mental Illness specialty case reviews and can be made available to elements of our core MSO.
WorldCare is the first MSO provider to offer a dedicated Mental Illness Expert Review. It covers:
- Bipolar disorder
- Generalized anxiety disorder
- Major depression
- Post-traumatic stress disorder
These reviews are led by psychiatrists experienced in virtual diagnosis and treatment.
Coverage now includes benign tumors that are clinically significant, complex, and pose a risk to health due to their size, location, or potential to cause complications.
Note: Benign tumors/cysts that are asymptomatic, non-progressive, and do not require medical intervention are excluded from the coverage. This would typically include benign tumors that are small, stable, and unlikely to cause complications.
PGx testing identifies how a patient’s genetics may influence their response to relevant medications.
This simple saliva test helps avoid costly and uncomfortable trial-and-error prescribing by identifying medications most likely to be effective and those that may cause side effects.
Includes: Burst fractures, fracture dislocation, odontoid fractures, hyperflexion/ hyperextension injuries, penetrating injuries.
Note: MSO can be provided only after member has received critical care and has seen a local specialist.
Condition must have caused or could lead to partial or total loss of motor and/or sensory function below the level of injury.
Coverage may vary. Members should contact their benefits administrator or insurance provider for details.
Connect With WorldCare
Learn how our Medical Second Opinion services can enhance your organization’s health and benefits offerings.